We focus on two fundamental questions regarding tissue regeneration: What are the molecular mechanisms driving the superior regenerative abilities observed in certain organisms compared to others? What are the adaptive mechanisms responsible for the decline in regeneration capacity during aging and diseases? To address these questions, we utilize flatworm planarians, mice, and human cell-derived organoids as research model systems in our laboratory.

Planarian Schmidtea mediterranea exhibits an unparalleled capacity to regenerate from an 8000-cell tissue fragment into a complete organism within a remarkably short period. Our current research investigate key intrinsic components regulating the function of the cellular agent of regeneration in planarians, i.e., the stem cells. In addition, our team explores how these organisms including diverse cell types maintain metabolic fitness to regenerate missing tissues.

We also investigate the role of translational regulation in tissue regeneration.

To validate our findings in mammals, our team have chosen to carry out this work initially in organoids. Inspired by the powerful regeneration ability of the planarian central nerve and musculature systems, we have developed a neural-muscular organoid system using organoid technology to model ALS from patient-derived iPS cells (Cell Reports, 2024). 

Collectively, we are dedicated to applying our discoveries from highly regenerative organisms, such as planarians, to studying aging and related neurodegenerative diseases. Our ultimate objective is to apply our findings to enhance our understanding of the diversity of nature. We anticipate that this knowledge will contribute to advancements in the development of innovative therapeutic approaches for aging and related neurodegenerative diseases.